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- 72 bpm
- PR - Normal (140ms)
- QRS - Normal (100ms)
- Cove-shaped ST elevation in lead V1 (<1mm) and V2 (3mm)
- Obliquely straight ST elevation V3 (4mm)
- Possible ST depression leads III, aVF - difficult to see due to baseline artifact
- P waves difficult to see due to baseline artifact - best seen in V2-3
- T wave inversion leads aVR, aVL, V1-2
- Brugada Syndrome
- Type 1 Pattern
- Given the history of central chest pain the presence of additional ACS must be considered especially given the flat ST elevation in V3 plus subtle inferior ST depression
This patient had known Brugada and thankfully brought his old ECG from 10 yrs ago with him which showed all changes to be longstanding.
What happened ?
Interestingly the patient had been lost to cardiology follow-up and had no AICD inserted for his Type 1 Brugada. Given the typical nature of the pain the patient had a coronary angiogram which revealed no evidence of coronary artery disease and he is awaiting an AICD insertion.
Brugada Resources / Cases
We've had a case of Brugada before on ECG ot the Week here, which also prompted a 'guest editoral' post by Dr Ken Grauer which you can find here.
I've copied the Brugada overview and resource section from our previous post below.
So what is Brugada Syndrome ?
It's an inherited sodium channelopathy, associated with sudden death and syncope due to polymorphic VT and, as in our case, VF.
Three types of ECG pattern are describe in Brugada, although only type 1 is considered diagnostic, as shown in our ECG.
Type 1 ECG pattern:
- Cove-shaped ST elevation of at least 2mm followed by a negative T wave in one or more of leads V1-3
- Document VF / polymorphic VT
- Family history of sudden cardiac death at <45 years
- Type 1 pattern ECG i n family members
- Inducibility of VT with programmed stimulation
- Nocturnal agonal respiration
- Attributed to self-terminating VF/polymorphic VT
Also check out the following great blog posts on Brugada:
- Brugada Syndrome - Life in the Fast Lane ECG Library
- An ECG Pattern You Need to Know - Academic Life in Emergency Medicine
- ECG Case of pre-syncope - Dr Ken Grauer's ECG Interpretation Blog
What to do about it ?
As an emergency physician encountering a case of suspected / likely Brugada it's easy, phone your cardiologist. For those patients with a Brugada pattern ECG with a history of syncope, arrest, or arrhythmias, definitive treatment is an AICD insertion. The incidental Brugada pattern in the otherwise well patient is a bit more controversial, again from an Emergency Medicine perspective phone your cardiology team. The CSANZ guideline contains a nice algorithm for the diagnostic approach to Brugada and also discusses management strategies in the incidental and asymptomatic Brugada.
We should also be aware that some drugs can cause Brugada-like ECG changes and should be avoided in patients with known or suspected Brugada. For more information on what not to give go to www.brugadadrugs.org which contains information for both clinicians and patients.
Check out these cases from Dr Smith's blog, here, and here, which illustrate Brugada-like changes secondary to drug therapy.
Avoiding certain drugs raises the question what should we give ?
The simple answer is electricity in the setting of acute arrhythmia.
In those patients experiencing an arrythmic storm, or having repeated ICD shocks then iv isoprenaline has been proven to be useful and is recommended in the CSANZ guidelines.
For chronic prevention of arrythmia's the only oral agent shown to work is quinidine, but this is often very difficult to source.
Ii is also worth noting that fever can unmask Brugada, due to impaired sodium channel function and aggressive management of fever should be instigated. Other potential precipitants include alcohol, hypokalaemia, cocaine, large carb meals, and very hot baths.
References / Further Reading
Life in the Fast Lane
- Chan TC, Brady WJ, Harrigan RA, Ornato JP, Rosen P. ECG in Emergency Medicine and Acute Care. Elsevier Mosby 2005.